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Tyramine is
an endogenous compound which exists in the brain as a trace
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amine.
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It is also an exogenous
compound which is found in foods such as cheese
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and wine. Although the level is very low, and it has a very rapid
turnover
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rate, it is possible that it is involved in the process of
neurotransmission.
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The hypertensive action
of the indirectly acting sympathomimetic
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tyramine is due to the release of NE from peripheral
noradrenergic nerves.
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The mechanism of action of tyramine in brain regions
that are involved in
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cardiovascular regulation is largely unknown.
Tyramine microinjected into
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the RVL (C1 area) elicits a dose-dependent decrease in arterial
pressure,
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heart rate and sympathetic renal nerve activity.
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Tyramine causes a release
of several granular amines (5-HT, NE, DA) in
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synaptosomes.
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