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1- Tyramine acts as a nonselective monoamine
releaser. Its effect
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is mimicked by amphetamine and fenfluramine.
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2-The inhibitory effect of tyramine on synaptic
transmission
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does not require action-potential propagation.
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3- The nonselective amine transporter blocker,
cocaine, mimicks
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the effect of tyramine by inducing presynaptic
inhibition.
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4-The excitatory synaptic inputs to bulbospinal
RVL neurons
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can be inhibited by norepinephrine,
dopamine and serotonin.
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5- The effect of tyramine is the resultant effect
of activation of all
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monoamine receptors by endogenous DA, NE, and
5-HT, and the
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availability of monoamine terminals in different
brainstem regions.
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