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1- Is tyramine a nonselective monoamine releaser like amphetamine
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and
fenfluramine?
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2- Does the effect of tyramine require action-potential
propagation?
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3- Does the effect of tyramine resists monoamine
transporter blockade
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by DMI, fluoxetine, cocaine?
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4- Could the nonselective amine transporter blocker
cocaine mimick the
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effect of tyramine by inducing presynaptic inhibition?
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5- Can the synaptic inputs to bulbospinal neurons be inhibited by
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activation of a2-adrenoceptors, dopamine (D2) and 5-HT1 receptors?
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6- Hypothesis: The effect of tyramine is the
resultant effect of activation
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of all monoamine receptors by endogenous DA, NE, and 5-HT, and
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the availability of monoamine terminals.
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