• Tyramine is an
endogenous compound which exists in the brain as a trace amine.
•
• It is also an
exogenous compound which is found in foods such as cheese and wine. Although the level is very low,
and it has a very rapid turnover rate,
it is possible that it is involved in the process of neurotransmission.
•
• The hypertensive
action of the indirectly acting sympathomimetic tyramine is due to the release of NE from
peripheral noradrenergic nerves.
•
•The mechanism of action of tyramine in brain regions that are
involved in cardiovascular
regulation is largely unknown. Tyramine microinjected into the RVL (C1 area) elicits a
dose-dependent decrease in arterial pressure, heart rate and sympathetic renal nerve
activity.
•
• Tyramine causes a
release of several granular amines (5-HT, NE, DA) in synaptosomes.