1- Tyramine acts as a nonselective monoamine releaser.
Its effect is mimicked by amphetamine and fenfluramine.
2-The inhibitory effect of tyramine on synaptic
transmission does not require action-potential propagation.
3- The nonselective amine transporter blocker, cocaine,
mimicks the effect of tyramine by inducing presynaptic inhibition.
4-The excitatory synaptic inputs to bulbospinal RVL
neurons can be inhibited by norepinephrine, dopamine and serotonin.
5- The effect of tyramine is the resultant effect of
activation of all monoamine receptors by endogenous DA, NE, and 5-HT, and the availability of
monoamine terminals in different brainstem regions.