1-
Is tyramine a nonselective monoamine releaser like amphetamine and fenfluramine?
2-
Does the effect of tyramine require action-potential propagation?
3-
Does the effect of tyramine resists monoamine transporter blockade by DMI, fluoxetine, cocaine?
4-
Could the nonselective amine transporter blocker cocaine mimick the effect of tyramine by inducing
presynaptic inhibition?
5-
Can the synaptic inputs to bulbospinal neurons be inhibited by activation of a2-adrenoceptors, dopamine (D2) and 5-HT1
receptors?
6-
Hypothesis: The effect of tyramine is the resultant
effect of activation of
all monoamine receptors by endogenous DA, NE, and 5-HT, and the availability of monoamine terminals.