1992 MD, Clinical Medicine, Hebei Zhang Jia Kou Medical College, China.
2005- Present, Assistant Professor, Department of Anatomy and Neurobiology, University of Tennessee, Health Science Center. Major: Neurobiology.
2004 -------- 2005, Research Scientist, Department of Anatomy and Neurobiology, University of California in Los Angeles, David Geffen School of Medicine.
Major: Psychology and Neurobiology.
1999 -------- 2003, Research Associate, Department of Anatomy and Neurobiology, Washington University in St Louis, School of Medicine,
1997 -------- 1998, Postdoctoral Fellow, Department of Physiology and Pharmacology, School of Medicine, St Louis University.
Major: physiology and pharmacology.
1990 -------- 1992, Internship, rotated in all clinical departments in First Affiliate Hospital of Zhang Jia Kou, College of Medicine.
1) The mechanisms of long lasting memory evoked by one-trail stimulation in the olfactory system by which a simulated sensor can be developed in environmental protection
2) Distribution of transient receptor potential channels (TRPs) in the brain and their roles played in the signaling transduction, especially in pain, olfaction and emotion.
3) The relationships between olfaction and pain, emotion and endocrine functions.
4) The application of stem cells of olfactory system in the neurologic damage or neural degenerate diseases.
5）Developing and testing possible pharmaceutical agents in treating chronic pain, ethanol or cocaine addiction.
1) " Activity-dependent plasticity of sensory synapses in the olfactory bulb", R03DC009049, NIDCD, Principle Investigator, July 2007—Jun 2011, $150,000.
2) "Long-term plasticity of inhibitory synapses in the main olfactory bulb", 3R03DC009049-03S1, NIDCD, Principle Investigator, Aug 2009----July 2010, $25,000.
3) “Expression of Transient Receptor Potential Channels in Main Olfactory Bulb”, William Webster Endowment Fund Award, $10,000. 2010-2011.
4) "Metabotropic glutamate receptors in the main olfactory bulb. 5R01DC003195, NIDCD, Co-investigator, Jan 2007--Dec 2011, $1,125,000.
Publications (CA: Corresponding Author):
1. Nai Q, Dong HW, Linster C. Ennis M. Activation of α1 and α2 noradrenergic receptors exert opposing effects on excitability of main olfactory bulb granule cells. Neurosci. 2010, 169:882-892.
2. Dong HW, Heinbockel T, Hamilton KA, Hayar A, Ennis M. Metabotropic glutamate receptors and dendrodendritic synapses in the main olfactory bulb. Annual New York Academy of Sciences 2009, 1170:224-238.
3. Dong HW CA, Hayar A, Callaway J, Yang XH, Nai Qiang, Ennis M. mGluR1 Activation enhances non selective cation currents and rhythmic bursting in external tufted cells. Journal of Neurosci. 2009, 38:11943-11953.
4. Nai Q, Dong HW, Hayar A, Linster C, Ennis M. Regulation of GABAergic inhibition of mitral cells by noradrenergic system in rat main olfactory bulb. J Neurophysiol 2009, 101: 2472-2484.
5. Dong HW CA, Hayar A. Ennis M. Activation of group I metabotropic glutamate receptors on main olfactory bulb granule cells and periglomerular cells enhances synaptic inhibition of mitral cells. J. Neurosci. 2007, 27:5654-5663.
6. Dong HW, Buonomano DV. A technique for repeated recordings in cortical organotypic slices. J. Neurosci. Method 2005, 146:69-75.
7. Dong HW, Wang QX, Valkova K, Gonchar Y, Burkhalter A. Experience-dependent development of feedforward and feedback circuits between lower and higher areas of mouse visual cortex. Vision Res 44: 3389-3400. 2004
8. Dong HW, Shao ZW, Nerbonne JM, Burkhalter A. Frequency-dependent balance of synaptic excitation and inhibition in interareal feed-forward and feedback circuits of mouse visual cortex. J Comp Neurol. 2004, 475:361-73.
9. Dong HW CA, Wang LH, Zhang M, Han JS. Decreased Dynorphin A (1-17) in the spinal cord of spastic rats after the compressive injury. Brain Res. Bull. 2005, 67:189-195.
10. Zhang M, Wang XM, Zhang DB, Xu GH, Dong HW, Yu YX, Han JS. Orphanin FQ antagonizes the inhibition of Ca2+ currents induced by m-opioid receptors. J. Mol. Neurosci. 2005, 25:21-27.
11. Dong HW, Gan Q, Knuepfer MM. Central CRF and adrenergic receptors mediate cocaine-induced hemodynamic response in rats. Brain Res 2001,893:1-10.
12. Tang NM, Dong HW, Wang XM, Tsui ZC, Han JS. Cholecystokinin antisense RNA increases the analgesic effect induced by electroacupuncture or low dose morphine: conversion of low responder rats into high responders. Pain 1997,71:71-80.
13. Dong HW, Zhang W, Shi YS, Roques BP, Han JS. The potentiation effect of RB101, enkephalin-degradation-enzyme inhibitor, on low frequency electroacupuncture analgesia. Journal of Chinese Pain 1996,2:33-37.
14. Tang NM, Dong HW, Zhang LX, Han JS. L365, 260, CCK-B receptor antagonist converse low responder rats to electroacupuncture into high responders. Journal of Chinese Pain 1996,2:103-106.
15. Dong HW CA, Davis JC, Ding SY, Nai, Q, Zhou FM, Ennis M. Expression of Transient Receptor Potential (TRP) Channel mRNA in the Mouse Olfactory Bulb. Submitted to Chemical Sense.
16. Dong HW CA , Nai Q, Ennis M, Theta Burst Stimulation (TBS) of Olfactory Nerve (ON) evoked long term synaptic plasticity in glomerular layer (GL) of rat main olfactory bulb (MOB). In preparation.
Conference Presentation and Abstracts:
1. Modulation of endogenous opioid and anti-opioid peptide on the acupuncture analgesia. Harvard Medical School, Brigham and Women’s hospital. 2004.
2. The balance of excitation and inhibition of the neurocircuits in cortical cortex. University of Tennessee, Health Science Center. 2005.
3. Theta burst stimulation (TBS) of olfactory nerve (ON) evoked long term synaptic plasticity in glomerular layer (GL) of rat main olfactory bulb (MOB). Capital Medical University. 2008
4. Theta burst stimulation (TBS) of olfactory nerve (ON) evoked long term synaptic plasticity in glomerular layer (GL) of rat main olfactory bulb (MOB). National Psychological Institute, 2008.
5. Metabotropic glutamate receptor’s modulation on the dendrodendritic synapses in the main olfactory bulb. Shang Hai Fudan Medical College, 2011.
6. Metabotropic glutamate receptor’s modulation on the dendrodendritic synapses in the main olfactory bulb. Nantong University, 2011.
7. Metabotropic glutamate receptor’s modulation on the dendrodendritic synapses in the main olfactory bulb. BIT’s Second World Congress of Neurotalk 2011.
Computer and Biological Skills:
Computational languanges: C/C++, Matlab, SPSS, Igor, Neurolab.
Software: Skillful of using various imaging, data analysis and office tools. Photoshop7.0, illustrator CS4, Origin 8.1, Coredraw 12.0, Minianalysis, Clampfit 10.0 and Microsoft office 2007.
Biological Skills: Expertise in in vivo and in vitro electrophysiology. Familiar with the general lab techniques in molecular biology, immunohistochemistry
Member, Society of Neuroscience since 1998.
Member, Association of Chemical Sense since 2005.